HP's TouchPad and Palm phones are dead, but webOS continues to enjoy some kind of existence as open-source technology. Following an initial beta release back at the end of August, Open webOS graduates to a 1.0 release today. This release makes it possible to fully port the OS to a host of new devices.Source: http://feedproxy.google.com/~r/Techcrunch/~3/-MLubbqxdiM/
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ScienceDaily (Sep. 27, 2012) ? By mimicking nature's own sensing mechanisms, bioengineers at UC Santa Barbara and University of Rome Tor Vergata have designed inexpensive medical diagnostic tests that take only a few minutes to perform. Their findings may aid efforts to build point-of-care devices for quick medical diagnosis of sexually transmitted diseases (STDs), allergies, autoimmune diseases, and a number of other diseases. The new technology could dramatically impact world health, according to the research team.
The rapid and easy-to-use diagnostic test consists of a nanometer-scale DNA "switch" that can quickly detect antibodies specific to a wide range of diseases. The research is described in an article published this month in the Journal of the American Chemical Society.
The design was created by the research group of Kevin W. Plaxco, a professor in UCSB's Department of Chemistry and Biochemistry. He noted that, despite the power of current diagnostic tests, a significant limitation is that they still require complex laboratory procedures. "Patients typically must wait for days or even weeks to receive the results of most STD tests," said Plaxco. "The blood sample has to be transported to the lab, its content analyzed by trained personnel, and the results sent back to the doctor's office. If we can move testing to the point of care, it eliminates the lag between testing and treatment, which would enhance the effectiveness of medical interventions, and, for infectious diseases like STDs, reduce transmission."
The key breakthrough underlying this new technology came from observing nature. "All creatures, from bacteria to humans, monitor their environments using amazing 'molecular nanoswitches' that signal the presence of a specific target by changing their structure," said Alexis Vall?e-B?lisle, a postdoctoral scholar and co-first author of the study. "For example, on the surface of our cells, there are millions of receptor proteins that detect various molecules by switching from an 'off state' to an 'on state.' The beauty of these switches is that they are able to work directly in very complex environments such as whole blood."
Plaxco's research group teamed with Francesco Ricci, professor at University of Rome Tor Vergata and co-first author of the paper, to build synthetic molecular switches that signal their state via a change in electric current. This change in current can be measured using inexpensive electronics similar to those in the home glucose test meter used by diabetics to check their blood sugar. Using these "nature-inspired" nanoswitches, the researchers were able to detect anti-HIV antibodies directly in whole blood in less than five minutes.
"A great advantage of these electrochemical nanoswitches is that their sensing principle can be generalized to many different targets, allowing us to build inexpensive devices that could detect dozens of disease markers in less than five minutes in the doctor's office or even at home," said Ricci.
The authors noted that it may take several years to bring the devices to the market.
The additional co-authors are Fan Xia of Huazhong University of Science and Technology in Wuhan, China; and Takanori Uzawa of Hokkaido University in Sapporo, Japan.
This work was funded by the National Institute of Health, the Fond Qu?b?cois de la Recherche sur la Nature et les Technologies; the Italian Ministry of University and Research (MIUR) project "Futuro in Ricerca;" and the Bill & Melinda Gates Foundation, through the Grand Challenges Explorations Grant.
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BAGHDAD (AP) ? Prisoners seized weapons and set off hours-long clashes with security guards at a prison in Saddam Hussein's hometown that left 12 dead, including 10 guards, before dozens of inmates managed to escape from the facility, Iraqi officials said Friday.
The escaped prisoners included al-Qaida suspects, said a provincial spokesman, though he could not say whether the terror group was behind the jailbreak in Tikrit, 130 kilometers (80 miles) north of Baghdad.
It was the latest embarrassing security lapse in Iraq, raising questions about the Shiite-led government's ability to ensure the country's security in the wake of the U.S. troop withdrawal last December.
The prison riot erupted on Thursday night, said Mohammed al-Assi, the spokesman for Salahuddin province where Tikrit is the provincial capital. Several inmates broke into the prison storeroom, grabbing weapons that were kept there and overpowering the guards, he said.
The prisoners then engaged in a long gun battle with security troops inside the facility before breaking out hours later. By Friday morning, government troops had regained control of the prison, al-Assi said, and a curfew was imposed in Tikrit.
"Everything is under control now. Our security forces are chasing the escaped prisoners and have already recaptured some," al-Assi told The Associated Press in a telephone interview.
A provincial health official, Raed Ibrahim, confirmed that 12 people died in the violence ? 10 prison guards and two inmates. He said 32 people were wounded in the clashes at the prison.
Qutaiba al-Jubouri, a lawmaker from the province, said a total of 81 inmates, including some who had been sentenced to death, managed to escape but that 36 of them were quickly recaptured.
"This is a regrettable security breach," said al-Jubouri, adding that an investigation will follow, "starting with the commanders of the security forces" at the prison.
He added that special forces were sent to Tikrit from Baghdad in order to put down the rioting. Security forces later dismantled three car bombs that were found parked near the prison.
Another lawmaker, Hakim al-Zamili, said the inmates burned all the prison records during the rioting, which will complicate efforts to track down those who escaped. He suggested the jailbreak was an inside job.
"This incident shows that Iraqi security troops are still unable to control the situation and that they are still being infiltrated by terrorists," added al-Zamili.
The Tikrit prison has been the scene of some stunning jailbreaks in the past. In 2009, 16 prisoners, including five al-Qaida-linked inmates awaiting execution, made their escape after plying open the bars on a prison bathroom window with a pipe wrench. At the time, the entire staff of the prison and the provincial prison official were detained for questioning. Six of the escaped inmates were later captured.
In 2010, a dozen detainees held on terrorism charges broke out of a prison in the southern city of Basra, disguised in police uniforms. And last year, al-Qaida smuggled weapons and grenades into a prison in Mosul, supposedly one of the country's most secure detention centers, and attempted an ultimately unsuccessful jailbreak that left 17 dead.
In Basra on Friday, gunmen shot dead the former governor, Mohammed al-Wailie, as he was driving his car in the city center, the police said. There were no immediate details or indications who was behind the attack.
__
Associated Press Writer Qassim Abdul-Zahra contributed to this report in Baghdad.
Source: http://news.yahoo.com/iraqi-convicts-riot-escape-prison-12-killed-103724779.html
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10487 readersJust in time for Halloween, novelist Anne Rice wrote a Facebook post critiquing Twilight?comparing Stephenie Meyer?s vampire characters to Rice?s famous Lestat de Lioncourt and Louis de Pointe du Lac. Rice wrote: ?Lestat and Louie feel sorry for vampires that sparkle in the sun. They would never hurt immortals who choose to spend eternity going to
5221 readersThe beloved Sookie Stackhouse series?the vampire novels behind HBO?s True Blood?will end next year. Novelist Charlaine Harris made the announcement on Facebook today: ?the final Sookie Stackhouse book, Dead Ever After, will be on sale May 2, 2013!? In less than an hour, the post generated more than two thousand ?likes? and three hundred comments. Last year,
2789 readersAuthor Suzanne Collins has grabbed the #11 spot on?the USA Today?s bestseller list with a book she published eight years ago. The Hunger Games novelist hit the chart with her 2004 release,?Gregor the Overlander: Underland Chronicles Book One, following a special sale. Have you read this older series? Here?s more from Book Buzz: ?Why the high spot
10051 readersThe Spiderwick Chronicles author Holly Black has inked a deal for a YA vampire novel titled The Coldest Girl in Coldtown with Little Brown Books for Young Readers. Black?(pictured,?via) wrote a short story by the same name for a vampire anthology, The Eternal Kiss. In her blog announcement, Black?emphasized that the vampire tale is ?loosely based?
1277 readers This year?s New Yorker Festival took place last weekend.? Twitter fans at the festival used the hashtag, #tnyfestival. On Saturday, Joan Acocella (author of the vampire essay, ?In the Blood?) moderated the Vampires Revival panel. On board to speak were philosophy professor Noel Carroll, horror novelist Stephen King, vampire film director Matt Reeves, and Twilight screenwriter
2027 readersToday we have a new set of 2011 literary resolutions from writers. Share your resolutions in the comments section or?on Twitter. The Chronicles of Vladimir Tod vampire series writer Heather Brewer: ?1. FINALLY read Mockingjay (I am SO far behin...
6634 readersIn honor of the 100th anniversary of Bram Stoker?s death, the Horror Writers Association (HWA) has announced the nominees for the ?Bram Stoker Vampire Novel of the Century Award.? Below we?ve listed the nominees?did they miss anything? A winner will be revealed at the Bram Stoker Awards Banquet at World Horror Convention in Salt Lake City,
2853 readersOne of the many approaches I?m trying in order to build an audience for my novel, The Vampire Kitty-cat Chronicles, is doing the whole novel as free podcasts, one per chapter, 26 in all. Here?s how I I?m going about it, and the tools I use. The first podcast in the series is at the
7110 readersAuthor Colleen Hoover launched her career with the help of Avett Brothers fans. This week, her dramatic series rose up our self-published bestseller list. To help GalleyCat readers discover self-published authors, we have compiled lists of the top eBooks in three major marketplaces for self-published digital books: Amazon, Barnes & Noble and Smashwords. We will
11185 readersR.L. Stine, the author of the popular Goosebumps horror series for kids, gave his nearly 49,000+ Twitter followers another free story this afternoon. To celebrate Friday the 13th, the novelist tweeted a mini-horror story called ?The Brave One.? We?ve collected the posts below for your reading pleasure. His newest book, The 13th Warning, was published on Friday
Source: http://workflowwriting.com/676167/anne-rice-ponders-lestat-comeback-on-facebook.php
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ScienceDaily (Sep. 25, 2012) ? The process researchers use to generate induced pluripotent stem cells (iPSCs) -- a special type of stem cell that can be made in the lab from any type of adult cell -- is time consuming and inefficient. To speed things up, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) turned to kinase inhibitors. These chemical compounds block the activity of kinases, enzymes responsible for many aspects of cellular communication, survival, and growth.
As they outline in a paper published September 25 in Nature Communications, the team found several kinase inhibitors that, when added to starter cells, help generate many more iPSCs than the standard method. This new capability will likely speed up research in many fields, better enabling scientists around the world to study human disease and develop new treatments.
"Generating iPSCs depends on the regulation of communication networks within cells," explained Tariq Rana, Ph.D., program director in Sanford-Burnham's Sanford Children's Health Research Center and senior author of the study. "So, when you start manipulating which genes are turned on or off in cells to create pluripotent stem cells, you are probably activating a large number of kinases. Since many of these active kinases are likely inhibiting the conversion to iPSCs, it made sense to us that adding inhibitors might lower the barrier."
According to Tony Hunter, Ph.D., professor in the Molecular and Cell Biology Laboratory at the Salk Institute for Biological Studies and director of the Salk Institute Cancer Center, "The identification of small molecules that improve the efficiency of generating iPSCs is an important step forward in being able to use these cells therapeutically. Tariq Rana's exciting new work has uncovered a class of protein kinase inhibitors that override the normal barriers to efficient iPSC formation, and these inhibitors should prove useful in generating iPSCs from new sources for experimental and ultimately therapeutic purposes." Hunter, a kinase expert, was not involved in this study.
The promise of iPSCs
At the moment, the only treatment option available to many heart failure patients is a heart transplant. Looking for a better alternative, many researchers are coaxing stem cells into new heart muscle. In Alzheimer's disease, researchers are also interested in stem cells, using them to reproduce a person's own malfunctioning brain cells in a dish, where they can be used to test therapeutic drugs. But where do these stem cells come from? Since the advent of iPSC technology, the answer in many cases is the lab. Like their embryonic cousins, iPSCs can be used to generate just about any cell type -- heart, brain, or muscle, to name a few -- that can be used to test new therapies or potentially to replace diseased or damaged tissue.
It sounds simple enough: you start with any type of differentiated cell, such as skin cells, add four molecules that reprogram the cells' genomes, and then try to catch those that successfully revert to unspecialized iPSCs. But the process takes a long time and isn't very efficient -- you can start with thousands of skin cells and end up with just a few iPSCs.
Inhibiting kinases to make more iPSCs
Zhonghan Li, a graduate student in Rana's laboratory, took on the task of finding kinase inhibitors that might speed up the iPSC-generating process. Scientists in the Conrad Prebys Center for Chemical Genomics, Sanford-Burnham's drug discovery facility, provided Li with a collection of more than 240 chemical compounds that inhibit kinases. Li painstakingly added them one-by-one to his cells and waited to see what happened. Several kinase inhibitors produced many more iPSCs than the untreated cells -- in some cases too many iPSCs for the tiny dish housing them. The most potent inhibitors targeted three kinases in particular: AurkA, P38, and IP3K.
Working with the staff in Sanford-Burnham's genomics, bioinformatics, animal modeling, and histology core facilities -- valuable resources and expertise available to all Sanford-Burnham scientists and the scientific community at large -- Rana and Li further confirmed the specificity of their findings and even nailed down the mechanism behind one inhibitor's beneficial actions.
"We found that manipulating the activity of these kinases can substantially increase cellular reprogramming efficiency," Rana said. "But what's more, we've also provided new insights into the molecular mechanism of reprogramming and revealed new functions for these kinases. We hope these findings will encourage further efforts to screen for small molecules that might prove useful in iPSC-based therapies."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/dN6VwlNnmS0/120925121351.htm
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Makers and sellers of consumer-electronics devices have been releasing their earnings reports for the latest quarter. Here's a look at selected companies that report unit sales on phones, tablet computers and other devices. Some companies including Samsung Electronics Co. do not release data on unit sales.
? July 19: Microsoft Corp. says it shipped 1.1 million Xbox 360 consoles during the April-June period, down from 1.7 million a year earlier.
Nokia Corp. says sales of smartphones dropped 39 percent from a year ago to 10.2 million in the second quarter. The company blamed "strong momentum" of competing smartphones. All regions showed a decline except North America, where sales of the new Windows-based Lumia line offset declines in traditional Symbian devices. Sales of all cellphones fell 5 percent to 83.7 million.
? July 24: Apple Inc. says it sold 26 million iPhones, 28 percent more than a year ago. It also sold 17 million iPads, an 84 percent increase. But average selling prices for both products were down. Apple sold 4 million Macs, a 2 percent increase, and 6.8 million iPods, a 10 percent decline.
TomTom says it sold 1.7 million personal-navigation devices in North America, down from 2.1 million a year ago. In Europe, it sold 2.4 million, down from 2.8 million. TomTom says market share was relatively flat at 45 percent in Europe, but down to 19 percent from 23 percent in North America because of a GPS chip product issue.
AT&T Inc. says it activated 5.1 million smartphones in its latest quarter, down from 5.5 million in the same period a year ago. Much of the decline came because AT&T subscribers are holding on to their phones longer.
? July 25: Nintendo Co. says it sold 710,000 Wii units in the April-June quarter, down from 1.56 million a year ago. Nintendo is coming out with a successor, the Wii U, this year. It is forecasting 10.5 million units for the full fiscal year, which ends in March 2013. The company, meanwhile, sold 540,000 DS units, down from 1.44 million a year ago, and it sold 1.86 million 3DS units, up from 710,000 a year ago.
? Aug. 1: Garmin Ltd. says it sold 3.9 million GPS navigation and other devices in the second quarter, up 4 percent from a year earlier.
? Aug. 2: Sony Corp. says it sold 2.8 million PlayStation units, down from 3.2 million a year earlier. The figures cover both PlayStation 3 and the older PlayStation 2. Sales of the PlayStation Portable and Vita devices were at 1.4 million, down from 1.8 million a year earlier.
? Sept. 6: Samsung says global sales of its Galaxy S III smartphone have surpassed 20 million in a little more than three months. Samsung Electronics Co. launched the flagship smartphone powered by Google's Android operating system in Europe in late May. The U.S. got it in June.
Coming up:
? Sept. 27: Research In Motion Ltd.
Source: http://news.yahoo.com/consumer-electronics-makers-faring-230649861.html
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Upstream speeds are frequently the bottlenecks for cloud storage: an entire company might be held back waiting for that last presentation video to go online before the big meeting. Box wants much more parity through Accelerator, a custom infrastructure that should make uploads hum. It uses Amazon's EC2 for help, but the real magic comes through a mix of Box's own network and special prioritization. Accelerator goes beyond just location to factor in the browser, OS and other criteria that could affect a data packet's journey. The company claims through outside studies that its average 7MB/s speeds make it the upload king by a wide margin, to the tune of 2.7 times its fastest worldwide rival and 3.1 times any of its American counterparts. Peak speeds are up to 10 times faster than before, if you go by the company's word. Most of the focus is on corporate customers and speeding up access near the provider's ten global access points, but Box is planning both to ramp up performance in more areas and bring Accelerator to the company's syncing platforms in the near future -- an obvious lure for would-be Dropbox customers.
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Associated Press Sports
updated 11:42 p.m. ET Sept. 11, 2012
PANAMA CITY (AP) - Rolando Blackburn scored in the 26th minute and Blas Perez added a goal in the 56th to lead Panama over Canada 2-0 Tuesday night in a World Cup qualifier.
Blackburn out-jumped defenders to score on a header off a post. Perez scored off a pass from Alberto Quintero.
Panama (3-1) leads Group C of the North and Central American and Caribbean semifinals with nine points, followed by Honduras and Canada (both 2-1-1) with seven points each, with the Central Americans ahead of goal difference. Cuba (0-4) is last.
The top two nations advance to next year's regional finals, which will produce three qualifiers for the 2014 tournament in Brazil.
Canada hosts Cuba on Oct. 12, when Honduras is at Panama. In the final group games four days later, Panama is at Cuba and Canada is at Honduras.
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsPST: The 1-0 win vs. Jamaica wasn't perfect, so here are 10 things to ponder ? including Jurgen Klinsmann's perplexing player choices.
Source: http://nbcsports.msnbc.com/id/48997845/ns/sports-soccer/
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Baltimore Orioles' J.J. Hardy hits a two-run home run in the third inning of a baseball game against the Tampa Bay Rays in Baltimore, Tuesday, Sept. 11, 2012. (AP Photo/Patrick Semansky)
Baltimore Orioles' J.J. Hardy hits a two-run home run in the third inning of a baseball game against the Tampa Bay Rays in Baltimore, Tuesday, Sept. 11, 2012. (AP Photo/Patrick Semansky)
Baltimore Orioles starting pitcher Jason Hammel walks off the field after injuring his right knee in the fourth inning of a baseball game against the Tampa Bay Rays in Baltimore, Tuesday, Sept. 11, 2012. (AP Photo/Patrick Semansky)
Tampa Bay Rays starting pitcher Matt Moore throws to the Baltimore Orioles in the third inning of a baseball game in Baltimore, Tuesday, Sept. 11, 2012. (AP Photo/Patrick Semansky)
Tampa Bay Rays' Ryan Roberts hits a solo home run in the third inning of a baseball game against the Baltimore Orioles in Baltimore, Tuesday, Sept. 11, 2012. (AP Photo/Patrick Semansky)
Baltimore Orioles' J.J. Hardy, center, high-fives teammates after hitting a two-run home run in the third inning of a baseball game against the Tampa Bay Rays in Baltimore, Tuesday, Sept. 11, 2012. (AP Photo/Patrick Semansky)
BALTIMORE (AP) ? For the second time in three games, the Baltimore Orioles had an uplifting victory marred by an injury to a key player.
J.J. Hardy homered twice, doubled and drove in five runs, and the Orioles defeated the Tampa Bay Rays 9-2 Tuesday night to move into a tie for the AL East lead.
But starting pitcher Jason Hammel left in the fourth inning with an injured right knee. The right-hander underwent arthroscopic surgery on that same knee in mid-July and was making his second start since returning from the disabled list.
Hammel will be examined Wednesday by the team surgeon. He said the sensation was exactly identical to what he felt in a July 13 game against Detroit, his last start before going on the DL.
"It's a very sharp pain in the knee in the same spot," Hammel said. "I'm hoping it is just scar tissue. I've been told scar tissue can react like that."
On Saturday, Baltimore lost right fielder Nick Markakis with a broken left thumb while defeating the New York Yankees. Both Hammel and Markakis were on the DL earlier this year.
"We've been down this road many times this year with a lot of different challenges," manager Buck Showalter said. "We've operated a good portion of this season without Ham and without Nicky, so we're kind of experienced at it anyway. It's not the kind of experience you want to have."
Hammel had no problem with the knee on Thursday night against the Yankees, and retired 11 of 13 Tampa Bay batters before exiting.
"Against the Yankees, I felt great," Hammel said. "I felt like I was back on track, and I know I can help this team when I am healthy. So it's very frustrating."
Steve Johnson (3-0) got the win with 1 1-3 innings of hitless relief.
With Markakis out, Hardy picked up the slack. He went 4 for 5 to help Baltimore pull even atop the division with the Yankees, who lost 4-3 at Boston. The Rays are two games behind the co-leaders.
Hardy hit a two-run homer in the third inning, doubled and scored in the fifth, singled in a run in the sixth and added his 21st homer with a runner on in the eighth. It was his ninth career two-homer game, the second this season.
"I got a couple pitches to hit and didn't miss them," Hardy said.
Chris Davis homered and Matt Wieters had three hits and two RBIs for Baltimore.
Ryan Roberts and Elliott Johnson hit solo homers for Tampa Bay. It was the first time since Aug. 4 that the Rays lost by more than two runs; eight of their previous 12 defeats were by one run.
"Anybody can get beat by a lot of runs any night," Roberts said. "It didn't go our way tonight, and that's how it happens sometime in baseball."
Roberts left in the sixth inning with a left forearm strain, the result of a tag he made at second base. X-rays were negative, and he held out hope of playing Wednesday in the next game of the three-game series.
"I'm just glad it isn't broke," Roberts said. "If it's up to me, I'm playing. We're in a tight race and these games mean a lot, so I definitely want to play even if it's going to hurt a little bit."
Tampa Bay left-hander Matt Moore (10-10) threw 94 pitches over four innings before being lifted by manager Joe Maddon. Moore allowed two earned runs on four hits and three walks.
Burke Badenhop entered with a run of eight straight scoreless appearances and promptly gave up a double to Hardy, a single to Adam Jones and two-run double to Wieters that provided Baltimore with a 5-1 lead.
Hardy's sixth-inning RBI single came off Cesar Ramos and Davis hit his 25th homer in the seventh off J.P. Howell.
Johnson connected against Darren O'Day leading off the eighth, and Hardy homered off Dane De La Rose in the bottom half.
The victory improved Baltimore's record against AL East foes to 33-24 compared to 28-44 last year.
Baltimore broke on top with an unearned run in the first inning. Jones walked and scored when Matt Joyce fumbled Wieters' two-out single to right.
Hammel retired the first eight batters before Roberts connected in the third. It was his fourth homer with Tampa Bay since in coming over in a trade with Arizona on July 24.
In the bottom half, Robert Andino led off with a double and Hardy homered to put the Orioles ahead for good.
NOTES: Baltimore leads the season series 7-6 and took the lead in the all-time series, 127-126. ... The Orioles purchased the contracts of OFs Endy Chavez and L.J. Hoes and designated RHP Kevin Gregg and INF Ryan Adams for assignment. ... This was the first of 15 consecutive games against AL East foes for the Rays, who head to Yankee Stadium after this series. ... The Rays will send Alex Cobb to the mound Wednesday night and the Orioles will start rookie Miguel Gonzalez, who's 0-1 with a 6.52 ERA in two starts against Tampa Bay.
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SAN FRANCISCO (AP) ? Jeff Karp, the chief marketing and chief revenue officer at Zynga, has become the latest executive to leave the struggling online company behind "FarmVille" and other games.
In August, Chief Operating Officer John Schappert left the company after less than a year and a half on the job. Schappert's exit was followed by that of Mike Verdu, the company's chief creative officer.
Karp was hired at Zynga Inc. in August 2011.
Zynga says the groups that Karp oversaw have been moved to other divisions in the company. That means he is not being replaced.
"We are grateful to Jeff for his contributions over the last year and wish him well in his future endeavors," Zynga said in a statement.
Karp will get severance worth three months of his salary and Zynga will accelerate the vesting of 100,000 of stock he has received.
San Francisco-based Zynga's stock closed down 6 cents, or 2 percent, at $2.82 on Monday. The stock is down 72 percent from its December initial public offering price of $10.
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